Vandeputte,, M.,; Mauger,, S.; Dupont‐Nivet., M. From theory to practice: empirical evaluation of the assignment power of marker sets for pedigree analysis in fish breeding. Meta-analysis of the current study and relevant published data was undertaken. “Genomic and Expression Signatures of Glycemic Traits”, Twelfth annual Angeline Heaton Lecture for the Human Medical Genetics and Genomics Program at the University of Colorado Anschutz Medical Campus, 22 Feb 2018 “Genes influencing type 2 diabetes, obesity and related traits”, Institute for Behavioral Genetics, Colloquium, CU Boulder Campus, 23 Feb 2018 “Genes influencing type 2 diabetes, obesity and related traits”, Plenary Lecture, Biomarkers and Assay Development Course, Faculty of Pharmacy, University of Lisbon, 6-10 Feb2017“Genomic Approaches to Metabolic Disease”, Keynote Speaker, Target Validation using Genomics and Informatics, EMBL Heidelberg, Germany 4 - 6 Dec 2016 “Impact of genetic variation on type 2 diabetes risk, diagnosis and complications in ancestrally diverse populations”, APCDR workshop “Big Data for Health in Africa” invited speaker “The Uganda Genome Project”, 3-4 Nov 2016, TGAC, Norwich Seminar, 26th Oct 2016, “Genes and Metabolism”, EMBO Workshop on Cell Size Regulation, 14 – 18 Sep 2016, Joachimsthal, Germany, Keynote “Genes influencing metabolism and size”. Reece,, K.,; Ribeiro, W.; Gaffney, P.; Carnegie,, R.; Allen Jr., S. Microsatellite multiplex panels for genetic studies of three species of marine fishes: red drum (Sciaenops ocellatus), red snapper (Lutjanus campechanus), and cobia (Rachycentron canadum). The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. METHODS: the IRS-1 gene was scanned for mutations in 83 unrelated affected subjects and 47 unaffected individuals using fluorescent single-strand conformation polymorphism (fSSCP) analysis. Liu,, P.,; Xia, J. H.; Lin, G.; Sun, F.; Liu, F.; Lim, H. S.; Pang,, H. Y.; Yue., G. H. Parentage assignment and parental contribution analysis in large yellow croaker Larimichthys crocea using microsatellite markers. However, we observed a significant total energy expenditure-haplotype interaction (P = 0.007). Vandeputte,, M.,; Rossignol,, M. N.; Pincent., C. Capillary electrophoresis is essential for microsatellite marker based detection and quantification of adulteration of Basmati rice (Oryza sativa). Dewoody,, J.,; Nason,, J. D.; Hipkins., V. D. Exclusion probabilities for pedigree testing farm animals. AB - This is a complete Journal issue. Pages Unit 2.2, Dye shift: a neglected source of genotyping error in molecular ecology. Copy and paste the desired citation format or use the link below to download a file formatted for EndNote. Wang,, C. M.,; Lo, L. C.; Zhu, Z. Y.; Lin, G.; Feng, F.; Li, J.; Yang, W. T.; Tan, J.; Chou, R.; Lim, H. S.; Orban,, L.; Yue., G. H. A 16‐microsatellite multiplex assay for parentage assignment in the eastern oyster (Crassostrea virginica Gmelin). AIMS: to define further the role of IRS-1 mutations in human syndromes of severe insulin resistance. Import into BibTeX METHODS: Four WFS1 SNPs (rs10010131, rs6446482, rs752854 and rs734312 [H611R]) were genotyped in a type 2 diabetes case-control study (n = 1,296/1,412) of Swedish adults. Other murine studies demonstrate that exercise increases PGC-1alpha mRNA expression. RESULTS: Combined analysis of both phases demonstrated association between HNF4A P2 SNPs (rs1884613 and rs2144908) and type 2 diabetes in the Ashkenazim (n = 991; P < 1.6 x 10(-6)). We examined 152 SNPs in 71 candidate genes for association with diabetes status and related phenotypes in 2,134 Caucasians in a case-control study and an independent quantitative trait (QT) cohort in the United Kingdom. In a case-control study of 517 U.K. Caucasian case subjects and 517 age- and sex-matched control subjects, the T-allele at this locus was significantly associated with type 2 diabetes in men (odds ratio = 1.42 [1.11-1.82], P = 0.005) but not women. Jones,, A. G.,; Small, C. M.; Paczolt,, K. A.; Ratterman., N. L. Revising how the computer program CERVUS accommodates genotyping error increases success in paternity assignment. VO - 41 The object was to test 1) the association of genetic variation in eNOS, as assessed by haplotype-tagging single nucleotide polymorphisms (htSNPs) with type 2 diabetes, and 2) the interaction between eNOS haplotypes and total energy expenditure on glucose intolerance. Whereas DNA bending was unaffected, DNA binding was drastically reduced in both mutants (to 5% of wild type activity in F154L, 17% in A158T). As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and approximately 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. RESULTS: in the northern Swedish study, the minor allele at rs752854 was associated with reduced type 2 diabetes risk [odds ratio (OR) 0.85, 95% CI 0.75-0.96, p=0.010]. To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one. The transcription factor sterol regulatory element binding protein (SREBP)-1c is intimately involved in the regulation of lipid and glucose metabolism. journal={journal of the audio engineering society}, Liu,, X. D.,; Zhao, G. T.; Wang, Z. Y.; Cai, M. Y.; Ye,, H.; Wang., Q. R. A nondestructive, rapid, reliable and inexpensive method to sample, store and extract high‐quality DNA from fish body mucus and buccal cells. Permalink: In cases and controls, the Gly482Ser genotype met Hardy-Weinberg expectations (P > 0.05 in both groups tested separately). To clarify the role of Gly482Ser in type 2 diabetes and related human metabolic phenotypes we genotyped this polymorphism in a case-control study and performed a meta-analysis of relevant published data. Renshaw,, M. A.,; Saillant, E.; Bradfield,, S. C.; Gold., J. R. FAMSPHERE: a computer program for parental allocation from known genotypic pools, Estimates of heritability and genotype‐environment interactions for body weight in sea bass (Dicentrarchus labrax L.) raised under communal rearing conditions. Bookmark this article. Thus, our aim was to replicate those associations in a northern Swedish case-control study of type 2 diabetes. volume={41}, TY - paper Taris,, N.,; Baron, S.; Sharbel, T. F.; Sauvage,, C.; Boudry., P. GIMLET: a computer program for analysing genetic individual identification data, Isolation and multiplex analysis of six polymorphic microsatellites in the Antarctic notothenioid fish, Trematomus newnesi. 41, no. A highly accurate, single PCR reaction for parentage assignment in Senegal sole based on eight informative microsatellite loci. No mutations were detected but a novel intragenic polymorphism was identified in the 5'UTR of XPA, in both MSSE-affected and unrelated normal individuals. Search We aimed to investigate whether data from a large-scale mapping approach would replicate this association in novel Ashkenazi samples and in U.K. populations and whether these data would allow us to refine the association signal. Y1 - October 1993 Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections. We therefore examined the effects of these variants on diabetes incidence and response to interventions in the Diabetes Prevention Program (DPP), in which a lifestyle intervention or metformin treatment was compared with placebo. Vandeputte,, M.,; Kocour, M.; Mauger, S.; Dupont‐Nivet, M.; De Guerry, D.; Rodina, M.; Gela, D.; Vallod, D.; Chevassus,, B.; Linhart., O. Progress in identification of specific genetic variants predisposing to the disease has been limited. Read and print from thousands of top scholarly journals. Moghim,, M.,; Heist, E. J.; Pourkazemi, M.; Siraj,, S. S.; Panadam., J. M. Novel microsatellites for multiplex PCRs in the Humpback grouper, Cromileptes altivelis (Valenciennes, 1828), and applications for broodstock management. As such it provides proof of principle that specific gene variants may, at least in part, explain susceptibility and resistance to common forms of human obesity. number={10}, Lien,, S.,; Gidskehaug, L.; Moen, T.; Hayes, B. J.; Berg, P. R.; Davidson, W. S.; Omholt,, S. W.; Kent., M. P. DNA marker technologies and their applications in aquaculture genetics, Extraction of genomic DNA using a new amino silica monolithic column. There was no heterogeneity among studies and no apparent publication bias. Here we describe a mutation in the gene encoding the protein kinase AKT2/PKBbeta in a family that shows autosomal dominant inheritance of severe insulin resistance and diabetes mellitus. Bruyn,, M.,; Parenti,, L. R.; Carvalho., G. R. Incidence and origin of null alleles in the (AC)n microsatellite markers. To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don’t already have one. However, molecular parentage analysis of a large number of individuals is still too expensive because some steps of molecular parentage analysis are very cost‐intensive. [This corrects the article DOI: 10.1371/journal.pgen.1005378.]. CONCLUSIONS/INTERPRETATION: the previously reported protective effect of select WFS1 alleles may be magnified by a lifestyle intervention. Ziegle,, J. S.,; Su, Y.; Corcoran, K. P.; Nie, L.; Eric Mayrand, P.; Hoff, L. B.; McBride, L. J.; Kronick,, M. N.; Diehl., S. R. High‐throughput genomic DNA extraction protocol from tilapia's fin tissue. Although no mutation has been detected in MSSE families, PTCH has not been excluded as the MSSE gene. Thiazolidinediones are a new class of antidiabetic agent that improve insulin sensitivity and reduce plasma glucose and blood pressure in subjects with type 2 diabetes. Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D. EP - We have previously found evidence that a common SREBF1c single-nucleotide polymorphism (SNP), located between exons 18c and 19c, is associated with an increased risk of type 2 diabetes. Weeks,, D. E.,; Conley,, Y. P.; Ferrell,, R. E.; Mah,, T. S.; Gorin., M. B. journal={journal of the audio engineering society}, Woolley,, A. T.,; Sensabaugh,, G. F.; Mathies., R. A. Multiplex genotyping of novel microsatellites from silver pomfret (Pampus argenteus) and cross‐amplification in other pomfret species, Isolation and characterization of 13 new microsatellite markers in the triangle mussel (Hyriopsis cumingii), Recent advances of genome mapping and marker‐assisted selection in aquaculture, A simple and affordable method for high throughput DNA extraction from animal tissues for PCR, Rapid and precise genotyping of porcine microsatellites. In the cohort studies, no association was observed between haplotypes and 2-h glucose (P > 0.10). pages={}, Our observations suggest that these mutants restrict wild-type PPARgamma action via a non-DNA binding, transcriptional interference mechanism, which may involve sequestration of functionally limiting coactivators.
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